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The University of Pittsburgh’s clinician and scientist Sandeep Jain and his team were able to find a new possibility for a childhood asthma nasal swab test. This point of care test could aid in identifying the certain subtype in asthma in children. Through a research that was published in 2021 in JAMA, the clinicians stated that more research, and clinical testing needs to be done, however the potential for diagnostics are very high.
Looking for the Puerto Rican and African American youth has a proven record of increase and African American men have a higher likelihood of dying from asthma as opposed to the other ethnicity. .
“Dr. Juan Celedón, M.D., Dr.P.H, the research’s senior author, Chief of Pulmonary Medicine at the UPMC Children’s Hospital of Pittsburgh and Professor of Pediatrics at Pitt University noted: It is a well-known fact which has been acknowledged that Asthma is the most prevalent long-term illness in children between the ages of birth to 14 years old, and it has a higher frequency of incidence and severity in Black and Puerto Rican children, therefore, these little patients require active intervention in terms of new medication and therapies.”
“Due to differences in the immune cells that influence the development of the disease and the manner in which patients react to various treatments, asthma can often be observed to have a range of presentations and characteristics which we define as having different endotypes. Therefore precise identification of the specific endotype of the subtype is crucial in the development of improved therapies.”
“The expression of eight T2 and T17 signature genes was then analyzed following the collection of nasal samples from a 459 youth which were a part of three studies. The genetic analysis of the collected swabs helped define the patients’ endotype. The study established that 23-29 percent had T2 high, 35-47 percent had T17-high whereas 30–38 percent had low-low endotype.”
In light of this, Dr. Celedon mentions: There is more data on T2 high endotype asthma than any other endotypes, Children and adult with T2-high have been studied and treated with specific and immunomodulatory therapies.
“We can now pivot towards the development of biologics for T17-high and low-low disease considering we have a straightforward nasal swab test to detect the other endotypes” But. . . “But,” the researchers point out, “this rapid test for asthma endotype may also aid in advancing other fields of asthma research.”
